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Understanding A-PHP Pellets: A Research Chemical Overview

Alpha-Pyrrolidinohexanophenone (α-PHP), also known as PV-7, is a synthetic cathinone belonging to the pyrovalerone derivative subgroup that has become prominent in research chemical literature since its emergence on the illicit market around 2014. At 4mmcchems, we provide high-quality A-PHP pellets specifically for laboratory research applications.

Chemical Profile

A-PHP is a higher homolog of alpha-PVP, structurally characterized by a pyrrolidine ring and an extended side chain linked to the α-carbon . Its IUPAC name is 1-phenyl-2-(pyrrolidin-1-yl)hexan-1-one, with a molecular formula of C₁₆H₂₃NO and a molecular weight of 245.36 g/mol. In its pure form, A-PHP typically appears as a crystalline solid or powder, though it may also present as beige or brown powder with transparent, white, or yellow crystallized shards .

The compound functions as a potent dopamine and norepinephrine reuptake inhibitor. Research indicates that A-PHP ranks among the top five compounds demonstrating selective blockade of dopamine and norepinephrine transporters, with reported hDAT Ki values of 0.0160±0.0044 μM and hNET Ki of 0.339±0.037 μM . Unlike amphetamine-class stimulants, A-PHP does not induce neurotransmitter release, functioning instead as a pure reuptake inhibitor similar to MDPV .

Research Context

A-PHP has been the subject of increasing scientific investigation due to its prevalence in forensic samples. The substance was first identified in Japan in 2014 and has since been detected in 21 EU member states, with controls implemented in at least seven member states . According to European Monitoring Centre data, A-PHP has been associated with at least 27 deaths and two acute poisoning cases across member states .

Preclinical research has demonstrated that A-PHP fully substitutes for the discriminative stimulus effects of both cocaine and methamphetamine in animal models. In drug discrimination studies, A-PHP substituted for cocaine with an ED₅₀ of 2.86 mg/kg and for (+)-methamphetamine with an ED₅₀ of 1.23 mg/kg . Intravenous self-administration experiments indicate that A-PHP exhibits higher potency as a reinforcer compared to several other cathinones, with peak responding observed at a 0.0125 mg/kg/infusion dose .

Recent investigations have also explored the neurotoxic potential of A-PHP. In vitro studies using murine neural stem/progenitor cell cultures demonstrated that the compound provokes toxicity through depolarization of resting membrane potential and activation of apoptotic, autophagic, and necroptotic pathways .

Quality Standards at 4mmcchems

Every batch of A-PHP pellets undergoes comprehensive analytical verification. Our products are accompanied by certificates of analysis documenting purity levels, chemical composition, and relevant spectroscopic data. We maintain complete batch records for all research chemicals, with HPLC data and mass spectrometry results available for each lot.

Documentation and Compliance

4mmcchems provides certificates of analysis and technical documentation to support research requirements. Our quality assurance framework includes standardized testing protocols and multi-stage verification processes.

Important Notice

A-PHP has been recommended for inclusion in Schedule II of the Convention on Psychotropic Substances of 1971 by the World Health Organization . The substance is controlled in multiple jurisdictions, including the United Kingdom (Class B), United States (Schedule I), and several other countries . Researchers must verify their legal authority to handle such compounds and comply with all applicable regulations in their location. Our products are supplied strictly for laboratory research purposes and are not intended for human consumption.

Every production batch undergoes rigorous analytical screening, including HPLC and GC-MS verification, to confirm chemical identity and purity levels exceeding 98%. Batch-specific certificates of analysis accompany each order, documenting molecular composition and quality metrics.

A-PHP pellets are supplied in secure, moisture-resistant packaging designed to preserve chemical integrity during transit and storage. 4mmcchems maintains complete batch records and provides third-party verification documentation upon request.